Publications.
Posters
Publications
PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression
Lakhia R. et al.
nature communications doi: 10.1038/s41467-022-32543-2
Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease
Lee EC, et al.
nature communications doi:10.1038/s41467-019-11918-y: 2019-09-12
microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
Hajarnis S, et al.
nature communications doi:10.1038/ncomms14395: 2017-02-16
Polysome shift assay for direct measurement of miRNA inhibition by anti-miRNA drugs.
Androsavich JR, et al.
Nucleic Acids Res. Jan 29;44(2):e13.: 2016-01-29
Anti-miRs Competitively Inhibit microRNAs in Argonaute Complexes
Hogan DJ, et al.
PLOS One Jul 3;9(7):e100951.: 2015-07-03
Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy
Dubinsky A, et al.
Cell Metabolism Oct 7;20(4):626-38.: 2014-10-07
Non-inhibited miRNAs shape the cellular response to anti-miR.
Androsavich JR, et al.
Nucleic Acids Res. Jun;42(11):6945-55.: 2014-06-01
Engineered microRNA therapeutics
Gibson NW, et al.
J R Coll Physicians 44(3):196-200.: 2014-01-01
An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis
Jeon TI, et al.
Cell Metabolism Jul 2;18(1):51-61.: 2013-07-02
What Goes Up Must Come Down: The Emerging Role of MicroRNA in Fibrosis
Chau BN, et al.
Hepatology Jan;53(1):4-6.: 2011-01-01
Hidden reach of the micromanagers
Linsley P, et al.
BMC Biology May 11;8:53.: 2010-05-11
The Therapeutic Potential of microRNA Modulation
Jackson A, et al.
Discovery Medicine 2010 Apr;9(47):311-8.: 2010-04-09
Prioritizing Genes for Pathway Impact Using Network Analysis
Chang AN, et al.
Protein Networks and Pathway Analysis 563:141-56.: 2009-01-01
Potent inhibition of microRNA in vivo without degradation
Davis S, et al.
Nucleic Acids Research Jan;37(1):70-7.: 2009-01-01
Inhibition of microRNA with antisense oligonucleotides
Christine Esau, et al.
Methods Jan;44(1):55-60.: 2008-01-01
Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC)
Dhanasekaran R, et al.
Oncotarget 2017 Nov 9;9(5):5517-5528.: 2017-11-09
Lipid Nanoparticle-Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth
Huang X, et al.
Shift of microRNA profile upon orthotopic xenografting of glioblastoma spheroid cultures.
Halle B, et al.
J Neurooncol. 11-Apr: 2016-04-11
Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic
Teplyuk NM, et al.
EMBO Molecular Medicine : 2016-02-09
J Neurooncol. Jan;126(1):47-55.: 2016-01-01
A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions.
Bertero T, et al.
Sci Rep. Dec 15;5:18277: 2015-12-15
microRNA-33 Regulates ApoE Lipidation and Amyloid-ß Metabolism in the Brain. Kim J, et al.
Kim J, et al.
J Neurosci. Nov 4;35(44):14717-26.: 2015-11-04
Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.
Bertero T, et al.
Cell Rep. Nov 3;13(5):1016-32.: 2015-11-03
miR-128 represses L1 retrotransposition by binding directly to L1 RNA.
Hamdorf M, et al.
Nat Struct Mol Biol. Oct;22(10):824-31.: 2015-10-22
miR33 Inhibition Overcomes Deleterious Effects of Diabetes Mellitus on Atherosclerosis Plaque Regression in Mice
Distel E, et al.
Circ Res. Oct 10;115(9):759-69.: 2015-10-10
Anti-miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation
Wagenaar TR, et al.
American Association for Cancer Research Jun;13(6):1009-21.: 2015-06-13
Altered lymphopoiesis and immunodeficiency in miR-142 null mice.
Kramer NJ, et al.
Blood. Jun 11;125(24):3720-30.: 2015-06-11
Genetic and hypoxic alterations of the microRNA- 210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension
White K, et al.
EMBO Molecular Medicine Mar 30;7(6):695-713.: 2015-03-30
A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver
Mattis AN, et al.
Hepatology Jan;61(1):141-52.: 2015-01-01
Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells
Wagenaar TR, et al.
Nucleic Acids Research Jan;43(2):1204-15.: 2015-01-01
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension
Bertero T, et al.
Journal of Clinical Investigation Aug;124(8):3514-28: 2014-08-01
Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice
Goedeke L, et al.
EMBO Molecular Medicine Jul 18;6(9):1133-41.: 2014-07-18
Mol Cancer Ther. Jul;13(7):1729-39.: 2014-07-13
Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis
Zhou W, et al.
Cancer Cell Apr 14;25(4):501-15.: 2014-04-14
MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma
Teplyuk N, et al.
Oncotarget Feb 28;6(6):3770-83.: 2014-02-28
The MicroRNA-130/301 Family Controls Vasoconstriction in Pulmonary Hypertension
Bertero T, et al.
Journal of Biological Chemistry Jan 23;290(4):2069-85.: 2014-01-23
Therapeutic silencing of microRNA-33 inhibits the progression of atherosclerosis in Ldlr-/- mice
Rotllan N, et al.
Arteriosclerosis, Thrombosis and Vascular Biology Aug;33(8):1973-7.: 2013-08-01
De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer’s disease
Wong HK, et al.
Human Molecular Genetics Aug 1;22(15):3077-92: 2013-08-01
MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor
de Aguiar Vallim TQ, et al.
Circulation Research Jun 7;112(12):1602-12: 2013-06-07
Prooncogenic factors miR-23b and miR-27b are regulated by Her2/Neu, EGF, and TNF-α in breast cancer
Jin L, et al.
Cancer Research May 1;73(9):2884-96: 2013-05-01
Reflections on MicroRNAs in Chronic Pulmonary Disease: Looking into the miR-ror and Crystal Ball
Karras JG, et al.
Inflammation & Allergy – Drug Targets Apr;12(2):88-98.: 2013-04-01
Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1
Morel L, et al.
Journal of Biological Chemistry Mar 8;288(10):7105-16: 2013-03-08
MyomiR-133 regulates brown fat differentiation through Prdm16
Trajkovski M, et al.
Dec;14(12):1330-5: Nature Cellular Biology
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
Rayner KJ, et al.
Nature Oct 19;478(7369):404-7.: 2011-11-19
MicroRNA-24 Regulates Vascularity After Myocardial Infarction
Fiedler J, et al.
American Heart Association Aug 9;124(6):720-30.: 2011-08-09
Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
Rayner KJ, et al.
Journal of Clinical Investigation Jul;121(7):2921-31.: 2011-07-01
MicroRNAs 103 and 107 regulate insulin sensitivity
Trajkovski M, et al.
Nature Jun 8;474(7353):649-53.: 2011-06-08
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
Boldin MP, et al.
Journal of Experimental Medicine Jun 6;208(6):1189-201.: 2011-06-06
Human Glioma Growth is Controlled by MicroRNA-10b
Gabriely G, et al.
Cancer Research May 15;71(10):3563-72.: 2011-05-15
miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor
Park JK, et al.
Biochem Biophys Res Commun Mar 25;406(4):518-23.: 2011-03-25
Comparison of different miR-21 inhibitor chemistries in a cardiac disease model
Thum T, et al.
Journal of Clinical Investigation Feb;121(2):461-2; author reply 462-3.: 2011-02-01
MicroRNA-122 modulates the rhythmic expression profile of the circadian deadenylase Nocturnin in mouse liver
Kojima S, et al.
PLOS One Jun 22;5(6):e11264: 2010-06-22
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model
Ma L, et al.
Nature Biotechnology Apr;28(4):341-7.: 2010-04-01
Pancreas Oct;38(7):e190-9: 2009-10-01
Integration of microRNA miR-122 in hepatic circadian gene expression
Gatfield D, et al.
Genes and Development Jun 1;23(11):1313-26: 2009-06-01
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators
Gabriely G, et al.
Molecular and Cellular Biology Sep;28(17):5369-80: 2008-09-01