PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression. PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression Post navigation Previous: Discovery of Next-generation Anti-miR-17 Oligonucleotide RGLS8429 for Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)Next: RGLS8429 Increases Urinary PC1 and PC2 and May Reduce Height-Adjusted Total Kidney Volume (htTKV) in Patients with ADPKD